Execution Profile is just one of the ways of passing parameter values to test suites. Katalon Studio provides other various ways.
- Data Driven Testing https://docs.katalon.com/katalon-studio/tutorials/data_driven_testing.html
- Let your TestListener READ you custom JSON files from somewhere (e.g.
<projectDir>/Data Files/configX.jsonand<projectDir>/Data Files/configY.json) : see [Katalon Profile] Dynamic Profile update upon execution
Combination of Execution Profile and other methods would make your life easier.
One Profile for one test suite execution. This is the given.
If you have many parameters and several categories, you should consider saving them in JSON files per category rather than storing them in an Execution Profile. You would want to write some metadata (which JSON files to load on test suite startup) in the Execution Profile. Your TestListener @BeforeTestSuite code can load as many JSON files as you would like.